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Universal laboratory testing for SARS-CoV-2 in hyperacute stroke during the COVID-19 pandemic.

Identifieur interne : 000097 ( Main/Exploration ); précédent : 000096; suivant : 000098

Universal laboratory testing for SARS-CoV-2 in hyperacute stroke during the COVID-19 pandemic.

Auteurs : Kristian Barlinn [Allemagne] ; Timo Siepmann [Allemagne] ; Lars-Peder Pallesen [Allemagne] ; Simon Winzer [Allemagne] ; Annahita Sedghi [Allemagne] ; Percy Schroettner [Allemagne] ; Kristina Hochauf-Stange [Allemagne] ; Alexandra Prakapenia [Allemagne] ; Haidar Moustafa [Allemagne] ; Katja De With [Allemagne] ; Jennifer Linn [Allemagne] ; Heinz Reichmann [Allemagne] ; Jessica Barlinn [Allemagne] ; Volker Puetz [Allemagne]

Source :

RBID : pubmed:32807466

Descripteurs français

English descriptors

Abstract

OBJECTIVE

Stroke patients are thought to be at increased risk of Coronavirus Disease 2019 (COVID-19). To evaluate yield of universal laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in acute stroke patients and its impact on hyperacute stroke care.

METHODS

Between weeks 14 and 18 in 2020, a protected code stroke protocol including infection control screening and laboratory testing for SARS-CoV-2 was prospectively implemented for all code stroke patients upon arrival to the emergency department. If infection control screen was positive, patients received protective hygienic measures and laboratory test results were available within four hours from testing. In patients with negative screen, laboratory results were available no later than the next working day. Door-to-imaging times of patients treated with thrombolysis or thrombectomy were compared with those of patients treated during the preceding weeks 1 to 13 in 2020.

RESULTS

During the 4-weeks study period, 116 consecutive code stroke patients underwent infection control screen and laboratory testing for SARS-CoV-2. Among 5 (4.3%) patients whose infection control screen was positive, no patient was tested positive for SARS-CoV-2. All patients with negative infection control screens had negative test results. Door-to-imaging times of patients treated with thrombolysis and/or thrombectomy were not different to those treated during the preceding weeks (12 [9-15] min versus 13 [11-17] min, p = 0.24).

CONCLUSIONS

Universal laboratory testing for SARS-CoV-2 provided useful information on patients' infection status and its implementation into a protected code stroke protocol did not adversely affect hyperacute stroke care.


DOI: 10.1016/j.jstrokecerebrovasdis.2020.105061
PubMed: 32807466
PubMed Central: PMC7305910


Affiliations:


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<name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name>
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<nlm:affiliation>Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. Electronic address: heinz.reichmann@ukdd.de.</nlm:affiliation>
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<name sortKey="Barlinn, Jessica" sort="Barlinn, Jessica" uniqKey="Barlinn J" first="Jessica" last="Barlinn">Jessica Barlinn</name>
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<name sortKey="Puetz, Volker" sort="Puetz, Volker" uniqKey="Puetz V" first="Volker" last="Puetz">Volker Puetz</name>
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<title level="j">Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association</title>
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<date when="2020" type="published">2020</date>
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<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>Clinical Decision-Making (MeSH)</term>
<term>Clinical Laboratory Techniques (MeSH)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Coronavirus Infections (virology)</term>
<term>Emergency Service, Hospital (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Infection Control (MeSH)</term>
<term>Male (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Patient Safety (MeSH)</term>
<term>Patient Selection (MeSH)</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Predictive Value of Tests (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Stroke (complications)</term>
<term>Stroke (diagnosis)</term>
<term>Stroke (therapy)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Accident vasculaire cérébral (complications)</term>
<term>Accident vasculaire cérébral (diagnostic)</term>
<term>Accident vasculaire cérébral (thérapie)</term>
<term>Betacoronavirus (isolement et purification)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (complications)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (thérapie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (complications)</term>
<term>Pneumopathie virale (diagnostic)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Prise de décision clinique (MeSH)</term>
<term>Prévention des infections (MeSH)</term>
<term>Service hospitalier d'urgences (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Sécurité des patients (MeSH)</term>
<term>Sélection de patients (MeSH)</term>
<term>Techniques de laboratoire clinique (MeSH)</term>
<term>Valeur prédictive des tests (MeSH)</term>
<term>Études prospectives (MeSH)</term>
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<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Stroke</term>
</keywords>
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<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr">
<term>Accident vasculaire cérébral</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
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<term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr">
<term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Stroke</term>
</keywords>
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<term>Accident vasculaire cérébral</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
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<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Clinical Decision-Making</term>
<term>Clinical Laboratory Techniques</term>
<term>Emergency Service, Hospital</term>
<term>Female</term>
<term>Humans</term>
<term>Infection Control</term>
<term>Male</term>
<term>Pandemics</term>
<term>Patient Safety</term>
<term>Patient Selection</term>
<term>Predictive Value of Tests</term>
<term>Prospective Studies</term>
<term>Risk Factors</term>
</keywords>
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<term>Accident vasculaire cérébral</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Pneumopathie virale</term>
<term>Prise de décision clinique</term>
<term>Prévention des infections</term>
<term>Service hospitalier d'urgences</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Sécurité des patients</term>
<term>Sélection de patients</term>
<term>Techniques de laboratoire clinique</term>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVE</b>
</p>
<p>Stroke patients are thought to be at increased risk of Coronavirus Disease 2019 (COVID-19). To evaluate yield of universal laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in acute stroke patients and its impact on hyperacute stroke care.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>Between weeks 14 and 18 in 2020, a protected code stroke protocol including infection control screening and laboratory testing for SARS-CoV-2 was prospectively implemented for all code stroke patients upon arrival to the emergency department. If infection control screen was positive, patients received protective hygienic measures and laboratory test results were available within four hours from testing. In patients with negative screen, laboratory results were available no later than the next working day. Door-to-imaging times of patients treated with thrombolysis or thrombectomy were compared with those of patients treated during the preceding weeks 1 to 13 in 2020.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>During the 4-weeks study period, 116 consecutive code stroke patients underwent infection control screen and laboratory testing for SARS-CoV-2. Among 5 (4.3%) patients whose infection control screen was positive, no patient was tested positive for SARS-CoV-2. All patients with negative infection control screens had negative test results. Door-to-imaging times of patients treated with thrombolysis and/or thrombectomy were not different to those treated during the preceding weeks (12 [9-15] min versus 13 [11-17] min, p = 0.24).</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>Universal laboratory testing for SARS-CoV-2 provided useful information on patients' infection status and its implementation into a protected code stroke protocol did not adversely affect hyperacute stroke care.</p>
</div>
</front>
</TEI>
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<Year>2020</Year>
<Month>08</Month>
<Day>24</Day>
</DateCompleted>
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<Year>2020</Year>
<Month>10</Month>
<Day>03</Day>
</DateRevised>
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<ISSN IssnType="Electronic">1532-8511</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>29</Volume>
<Issue>9</Issue>
<PubDate>
<Year>2020</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association</Title>
<ISOAbbreviation>J Stroke Cerebrovasc Dis</ISOAbbreviation>
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<ArticleTitle>Universal laboratory testing for SARS-CoV-2 in hyperacute stroke during the COVID-19 pandemic.</ArticleTitle>
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<MedlinePgn>105061</MedlinePgn>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Stroke patients are thought to be at increased risk of Coronavirus Disease 2019 (COVID-19). To evaluate yield of universal laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in acute stroke patients and its impact on hyperacute stroke care.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Between weeks 14 and 18 in 2020, a protected code stroke protocol including infection control screening and laboratory testing for SARS-CoV-2 was prospectively implemented for all code stroke patients upon arrival to the emergency department. If infection control screen was positive, patients received protective hygienic measures and laboratory test results were available within four hours from testing. In patients with negative screen, laboratory results were available no later than the next working day. Door-to-imaging times of patients treated with thrombolysis or thrombectomy were compared with those of patients treated during the preceding weeks 1 to 13 in 2020.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">During the 4-weeks study period, 116 consecutive code stroke patients underwent infection control screen and laboratory testing for SARS-CoV-2. Among 5 (4.3%) patients whose infection control screen was positive, no patient was tested positive for SARS-CoV-2. All patients with negative infection control screens had negative test results. Door-to-imaging times of patients treated with thrombolysis and/or thrombectomy were not different to those treated during the preceding weeks (12 [9-15] min versus 13 [11-17] min, p = 0.24).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Universal laboratory testing for SARS-CoV-2 provided useful information on patients' infection status and its implementation into a protected code stroke protocol did not adversely affect hyperacute stroke care.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
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<LastName>Barlinn</LastName>
<ForeName>Kristian</ForeName>
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<Affiliation>Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. Electronic address: kristian.barlinn@ukdd.de.</Affiliation>
</AffiliationInfo>
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<LastName>Siepmann</LastName>
<ForeName>Timo</ForeName>
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<Affiliation>Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. Electronic address: timo.siepmann@ukdd.de.</Affiliation>
</AffiliationInfo>
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<Affiliation>Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. Electronic address: alexandra.prakapenia@ukdd.de.</Affiliation>
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<LastName>Puetz</LastName>
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<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany. Electronic address: volker.puetz@ukdd.de.</Affiliation>
</AffiliationInfo>
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<CoiStatement>Declaration of Competing Interests The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.</CoiStatement>
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</country>
<region>
<li>District de Dresde</li>
<li>Saxe (Land)</li>
</region>
<settlement>
<li>Dresde</li>
</settlement>
<orgName>
<li>Université technique de Dresde</li>
</orgName>
</list>
<tree>
<country name="Allemagne">
<region name="Saxe (Land)">
<name sortKey="Barlinn, Kristian" sort="Barlinn, Kristian" uniqKey="Barlinn K" first="Kristian" last="Barlinn">Kristian Barlinn</name>
</region>
<name sortKey="Barlinn, Jessica" sort="Barlinn, Jessica" uniqKey="Barlinn J" first="Jessica" last="Barlinn">Jessica Barlinn</name>
<name sortKey="De With, Katja" sort="De With, Katja" uniqKey="De With K" first="Katja" last="De With">Katja De With</name>
<name sortKey="Hochauf Stange, Kristina" sort="Hochauf Stange, Kristina" uniqKey="Hochauf Stange K" first="Kristina" last="Hochauf-Stange">Kristina Hochauf-Stange</name>
<name sortKey="Linn, Jennifer" sort="Linn, Jennifer" uniqKey="Linn J" first="Jennifer" last="Linn">Jennifer Linn</name>
<name sortKey="Moustafa, Haidar" sort="Moustafa, Haidar" uniqKey="Moustafa H" first="Haidar" last="Moustafa">Haidar Moustafa</name>
<name sortKey="Pallesen, Lars Peder" sort="Pallesen, Lars Peder" uniqKey="Pallesen L" first="Lars-Peder" last="Pallesen">Lars-Peder Pallesen</name>
<name sortKey="Prakapenia, Alexandra" sort="Prakapenia, Alexandra" uniqKey="Prakapenia A" first="Alexandra" last="Prakapenia">Alexandra Prakapenia</name>
<name sortKey="Puetz, Volker" sort="Puetz, Volker" uniqKey="Puetz V" first="Volker" last="Puetz">Volker Puetz</name>
<name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name>
<name sortKey="Schroettner, Percy" sort="Schroettner, Percy" uniqKey="Schroettner P" first="Percy" last="Schroettner">Percy Schroettner</name>
<name sortKey="Sedghi, Annahita" sort="Sedghi, Annahita" uniqKey="Sedghi A" first="Annahita" last="Sedghi">Annahita Sedghi</name>
<name sortKey="Siepmann, Timo" sort="Siepmann, Timo" uniqKey="Siepmann T" first="Timo" last="Siepmann">Timo Siepmann</name>
<name sortKey="Winzer, Simon" sort="Winzer, Simon" uniqKey="Winzer S" first="Simon" last="Winzer">Simon Winzer</name>
</country>
</tree>
</affiliations>
</record>

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